An automated vacuum-assisted mesotherapy injection system from South Korea, designed to deliver skin boosters, polynucleotides, and other regenerative injectables with greater precision than manual injection.
DERMASHINE PRO® is an automated vacuum-assisted mesotherapy injection system developed in South Korea for delivering skin boosters, polynucleotides, hyaluronic acid, exosomes, and other regenerative injectables with greater precision and consistency than manual injections. Unlike products such as REJURAN, JUVELOOK, or JUVÉDERM, Dermashine Pro isn't a skin booster or filler itself, it's a medical injection device that administers these products into the skin in a controlled manner. The system has become widely adopted in Korean aesthetic clinics and is increasingly used internationally.
The defining feature of Dermashine Pro is its negative-pressure (vacuum) technology. Before each injection, the device gently suctions the skin, stabilizes it, and enters the needle at a controlled depth to deliver a pre-programmed amount of product before releasing the vacuum. This process aims to improve precision while reducing product loss and operator variability.
Unlike manual syringes, Dermashine Pro provides automated injection, digital depth control, precise dosing, consistent injection spacing, and uniform delivery across the treatment area. Because every injection is programmed, treatment is more standardized between practitioners and between sessions.
The system typically uses a sterile 9-pin disposable needle cartridge, enabling simultaneous microinjections, faster treatments, even product distribution, reduced treatment time, and greater efficiency for full-face procedures.
Dermashine Pro can deliver a wide variety of injectable products, including polynucleotides such as REJURAN, PDLLA collagen stimulators such as JUVELOOK and JUVELOOK Volume, hyaluronic acid skin boosters, and, subject to local regulations, exosome-based regenerative protocols and general mesotherapy solutions such as vitamins, amino acids, peptides, and hydrating cocktails. Suitability for any product depends on its approved indication and the clinician's judgment.
Protocols depend entirely on the injectable used: REJURAN is typically delivered over 3 to 4 sessions, JUVELOOK over 2 to 3 sessions, and HA skin boosters over 2 to 3 sessions, with maintenance roughly every 6 to 12 months. Dermashine Pro is simply the delivery system; the protocol follows the product being injected.
Because these risks exist with any injectable or energy-based treatment, procedures should only be performed by trained, licensed medical professionals with expertise in facial anatomy.
Dermashine Pro is widely used in South Korea and has expanded into markets including Australia, New Zealand, the United Kingdom, and Ireland, with local regulatory requirements differing by country. Clinics should ensure they're using legally supplied, compliant devices and approved injectable products.
DERMASHINE PRO is considered one of the most widely recognized automated mesotherapy injection systems in Korean aesthetic medicine. Rather than being a treatment itself, it serves as a precision delivery platform for injectable skin boosters, polynucleotides, collagen stimulators, and other regenerative therapies. Its combination of vacuum-assisted skin stabilization, digital depth control, and automated dosing helps improve consistency, reduce operator variability, and streamline high-volume treatment workflows. Current evidence suggests the clinical outcome is driven primarily by the injected product and the clinician's expertise, with the device mainly enhancing precision and treatment efficiency rather than the biological effect of the injectable itself.
See the DERMASHINE PRO device page for the treatments it powers at SAS Clinic and to book a session.
