A Swiss bio-remodeling injectable that improves skin hydration, elasticity, and firmness through patented NAHYCO® Hybrid Technology, without adding facial volume.
PROFHILO is a bio-remodeling injectable developed by IBSA Derma, a division of the Swiss pharmaceutical company IBSA Institut Biochimique SA. Unlike traditional dermal fillers that restore lost volume, or skin boosters that mainly hydrate, PROFHILO sits in its own category, designed to improve skin laxity, hydration, elasticity, and overall skin quality by stimulating the skin's natural regenerative processes. It was introduced in Italy in 2015 and is now marketed across Europe, Asia, Australia, the Middle East, and beyond.
PROFHILO's defining feature is IBSA's patented NAHYCO® Hybrid Technology. Rather than the chemical cross-linking (BDDE) used in conventional HA fillers, it combines high- and low-molecular-weight hyaluronic acid through a thermal stabilization process, forming Hybrid Cooperative Complexes that are stable yet highly diffusible through tissue rather than staying localized where injected.
Face, neck, décolletage, and hands - hydration, elasticity, firmness, mild skin laxity
Upper arms, abdomen, and knees - body skin laxity, often paired with topical body products
Deeper tissue remodeling for age-related facial volume changes
The standard protocol is 2 sessions, 30 days apart, using the BAP (Bio Aesthetic Points) technique - five carefully chosen injection points per side rather than numerous small injections, spreading the HA evenly while minimizing discomfort and bruising. Maintenance is typically every 4 to 6 months, individualized to age and skin condition.
Because these risks exist with any injectable or energy-based treatment, procedures should only be performed by trained, licensed medical professionals with expertise in facial anatomy.
PROFHILO is CE-marked and widely approved for aesthetic use across Europe, Asia, Australia, and many other markets. Approval status varies by country, and newer additions to the range such as Structura have expanded indications in selected regions.
PROFHILO is widely regarded as one of the gold-standard bio-remodeling treatments in aesthetic medicine. Its NAHYCO® Hybrid Technology, high concentration of non-cross-linked hyaluronic acid, and BAP injection protocol set it apart from both conventional dermal fillers and traditional skin boosters. Rather than adding facial volume, it focuses on restoring skin hydration, elasticity, firmness, and overall tissue quality, making it particularly effective for patients wanting subtle, natural-looking rejuvenation without changing facial contours.
