A polynucleotide-based skin booster and regenerative injectable from PharmaResearch Co., Ltd., designed to repair skin and stimulate tissue regeneration rather than add volume.
REJURAN is designed to repair damaged skin, stimulate tissue regeneration, improve skin quality, and enhance collagen production. Its active ingredient is highly purified long-chain polynucleotides (PN) extracted from wild Pacific salmon DNA, with roughly 97% DNA compatibility with human tissue. REJURAN has become one of Asia's most widely used regenerative injectable treatments and is distributed in more than 30 countries.
REJURAN's proprietary technology purifies and optimizes long-chain polynucleotides while preserving their biological activity, providing high biocompatibility, a stable molecular structure, minimal immunologic response, and long-lasting biological activity. Unlike PDRN products that contain shorter DNA fragments, REJURAN uses long-chain PN, intended to act as a scaffold supporting dermal repair and extracellular matrix remodeling.
Overall skin rejuvenation, fine wrinkles, barrier repair, elasticity, aging skin — the original formulation
Delicate areas — under-eye wrinkles, tear trough skin quality, crow’s feet — lower viscosity for precise injection into thin skin
Acne scars, depressed scars, localized scar remodeling — higher viscosity for scar support
PN + hyaluronic acid + lidocaine, for dry skin, hydration, fine lines, and improved comfort during treatment
Typical protocol is 3–4 treatment sessions every 3–4 weeks, with maintenance every 6–12 months. Many clinicians recommend an initial series before transitioning to maintenance treatments, and community experience suggests multiple sessions are generally needed to appreciate the full benefits.
Because these risks exist with any injectable or energy-based treatment, procedures should only be performed by trained, licensed medical professionals with expertise in facial anatomy.
REJURAN is widely approved and used throughout South Korea, Singapore, Indonesia, Australia, and many other Asian and international markets. Regulatory approval varies by country — injectable PN products, including REJURAN, are not FDA-approved in the United States, although topical PDRN products are available there.
REJURAN is widely regarded as the benchmark polynucleotide skin booster and one of the pioneers of regenerative injectable skin therapy. Rather than restoring volume, it focuses on improving the biological health of the skin — enhancing collagen synthesis, tissue repair, and barrier function over time. It's particularly valued for thin, damaged, or aging skin, under-eye rejuvenation, and acne scars, with one of the strongest clinical track records in Asia, though results develop gradually over multiple sessions rather than immediately.
